Is the Universe Indifferent? Should We Care

The thymus and rheumatology: should we care?

PURPOSE OF REVIEW The purpose of this review is to discuss the mechanisms of central and peripheral tolerance in relation to T-cell mediated autoimmunity in rheumatoid arthritis (RA). RECENT FINDINGS The well established association between major histocompatibility complex class II and RA has led us to understand that T cells, and the adaptive immune response, are important in the pathogenesi...

The Trans-Pacific Partnership: Should We “Fear the Fear”?; Comment on “The Trans-Pacific Partnership: Is It Everything We Feared for Health?”

RLabonté et al entitle their paper in this issue of the International Journal of Health Policy and Management “The Trans-Pacific Partnership: Is It Everything We Feared for Health?” Tantalisingly, they do not directly answer the question they pose, and in this commentary, we suggest that it is the wrong question; we should not ‘fear’ the Trans-Pacific Partnership (TPP) at all, rather we should ...

How Should We Pay for Health Care?

Professional attitudes: why we should care.

examining the media portrayal of doctors over the last twenty-one years, shows that more than twice as many negative articles are written as positive ones. Although the ratio remains unchanged over the period of the study, the authors noted that the language used to describe doctors appears to become more negative over time. In the UK the list of clinicians who have been seen to provide substan...

Why should we care about fly tumors?

Drosophila is proving to be a valuable model for studying aggressive tumors induced by the combined activation of EGFR and JAK-STAT signaling. Here we summarize some of the most recent data showing that tissue damage and the modulation of common pathway regulators are at the heart tumor progression and metastasis.